Oligosaccharides from faeces of a blood-group B, breast-fed infant

✍ Scribed by Hemant Sabharwal; Bo Nilsson; M.Alan Chester; Frank Lindh; Gunnar Grönberg; Sture Sjöblad; Arne Lundblad

• Book ID: 102993568
• Publisher: Elsevier Science
• Year: 1988
• Tongue: English
• Weight: 676 KB
• Volume: 178
• Category: Article
• ISSN: 0008-6215
• DOI: 10.1016/0008-6215(88)80107-1

✦ Synopsis

Eight oligosaccharides

have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 'H-n.m.r. spectroscopy.

One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-Whexaose.

The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis.

Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the oligosaccharide excretion in faeces from a blood group A infant [Sabharwal et al., Mol. Zmmunol., 21 (1984) 1105-11121 in which all the major oligosaccharides isolated were blood group A active.