𝔖 Bobbio Scriptorium
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Oligoribonucleotide synthesis from nucleoside 2′-O-benzyl ethers

✍ Scribed by Beverly S. Griffin; C.B. Reese; G.F. Stephenson; D.R. Trentham


Book ID
104215730
Publisher
Elsevier Science
Year
1966
Tongue
French
Weight
250 KB
Volume
7
Category
Article
ISSN
0040-4039

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2′-O-Propargyl oligoribonucleotides: Syn
✍ Morten Grøtli; Mark Douglas; Ramon Eritja; Brian S. Sproat 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 850 KB

Fully modified oligonucleotide sequences containing 2'-O-propargylribonucleotides were synthesised on automated DNA-synthesisers using the phosphoramidite approach. A highly selective alkylation procedure was used to introduce the propargyl functionality, thereby enabling the synthesis of protected