Oligopeptide-mediated acceleration of amyloid fibril formation of amyloid β(Aβ) and α-synuclein fragment peptide (NAC)
✍ Scribed by Dr Yoshihiro Kuroda; Yoshitaka Maeda; Hirofumi Hanaoka; Kazuhide Miyamoto; Terumichi Nakagawa
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 338 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.485
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## Abstract Aβ~16–22~ (Ac‐KLVFFAE‐NH~2~) is one of the shortest amyloid fibril‐forming sequences identified in β‐amyloid peptide. At neutral pH, the peptide forms fibrils in the concentration range of 0.2–2.0 mM after ≥ 10 days of incubation. Structures of the fibrils proposed based on solid‐state