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Oligonucleotide Analogues with Integrated Bases and Backbones. Part 23 : Conformational Analysis and Association of Sulfonyl- and Sulfinylmethylene Adenosine and Uridine Dinucleosides

✍ Scribed by Nicolas Bogliotti; Bruno Bernet; Andrea Vasella

Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
269 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The sulfone 2, and the sulfoxides (S)‐3 and (R)‐3 were obtained by oxidation of the thiomethylene‐linked A*[s]U dinucleoside 1. Conformational analysis and association studies of 2, (S)‐3, and (R)‐3 reveal a strong influence of the configuration on the conformation of the linking unit and on the self‐association of the dinucleosides.

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