Oligomycin resistance in yeast. Linkage of the mitochondrial drug resistance
โ Scribed by K. Wakabayashi; S. Kamei
- Book ID
- 115903511
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- English
- Weight
- 249 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0014-5793
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With a view towards identifying new ATPase loci on the mitochondrial genome a large number of oligomycin-, ossamycin- and venturicidin-resistant mutants were isolated after MnCl2 mutagenesis. The mutants were subjected to mass-screens which divided them into different cross-resistance phenotype-clas
The mitochondrial ATPase from oligomycin-resistant mutants which map on different regions of an extrachromosomal DNA (01 and 011 class mutants) showed an increased resistance to oligomycin and venturicidin when assayed in vitro as compared to the sensitive strains. The resistance to oligomycin of th