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Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

✍ Scribed by Berman, Diego E; Dall'Armi, Claudia; Voronov, Sergey V; McIntire, Laura Beth J; Zhang, Hong; Moore, Ann Z; Staniszewski, Agniezka; Arancio, Ottavio; Kim, Tae-Wan; Di Paolo, Gilbert

Book ID
109938066
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
687 KB
Volume
11
Category
Article
ISSN
1097-6256

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## Abstract The type I phosphatidylinositol 4‐phosphate 5‐kinases (PI4P5K) phosphorylate phosphatidylinositol 4‐phosphate [PI(4)P] to produce phosphatidylinositol 4,5‐bisphosphate [PI(4,5)P~2~]. PI(4,5)P~2~ has been implicated in signal transduction, receptor mediated endocytosis, vesicle trafficki