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Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives

โœ Scribed by Rachel H Woodruff; Nicoletta Tekki-Kessaris; Charles D Stiles; David H Rowitch; William D Richardson


Book ID
117563483
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
228 KB
Volume
19
Category
Article
ISSN
0736-5748

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## Abstract Oligodendrocytes (OL), cells that myelinate axons in the CNS, differentiate from early to late oligodendrocyte progenitor cells (OPC) to become mature OL. Unlike the case in the rodent brain, myelin formation starts prenatally in the human brain, but the sequence of OL development and t

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The earliest oligodendrocyte precursors have been proposed to arise in the ventral ventricular zone of the embryonic thoraco-lumbar spinal cord and subsequently migrate to populate dorsal spinal cord. Using the expression of O4 immunoreactivity to define cells of the oligodendrocyte lineage, the dev