## Abstract Oligodendrocytes (OL), cells that myelinate axons in the CNS, differentiate from early to late oligodendrocyte progenitor cells (OPC) to become mature OL. Unlike the case in the rodent brain, myelin formation starts prenatally in the human brain, but the sequence of OL development and t
Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives
โ Scribed by Rachel H Woodruff; Nicoletta Tekki-Kessaris; Charles D Stiles; David H Rowitch; William D Richardson
- Book ID
- 117563483
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 228 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0736-5748
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Oligodendrocyte precursors originate in the ventral ventricular zone of the developing spinal cord. To examine whether the notochord is essential for the development of oligodendrocytes in Xenopus spinal cord the notochord was prevented from forming, ablated, or transplanted during early stages of d
The earliest oligodendrocyte precursors have been proposed to arise in the ventral ventricular zone of the embryonic thoraco-lumbar spinal cord and subsequently migrate to populate dorsal spinal cord. Using the expression of O4 immunoreactivity to define cells of the oligodendrocyte lineage, the dev