## Abstract The reaction of oligodendrocyte progenitor cells (OPCs) after spinal cord injury (SCI) is poorly understood. In this study, we examined oligodendroglial reactions after contusion SCI in adult rats by immunohistochemistry. OPCs were identified by staining with monoclonal antibodies (mAbs
Apoptosis and proliferation of oligodendrocyte progenitor cells in the irradiated rodent spinal cord
β Scribed by Shelley L. Atkinson; Yu-Qing Li; C. Shun Wong
- Book ID
- 118455135
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 372 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0360-3016
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Following spinal cord contusion in the rat, apoptosis has been observed in the white matter for long distances remote from the center of the lesion and is primarily associated with degenerating fiber tracts. We have previously reported that many of the apoptotic cells are oligodendrocytes. Here we s
We have previously described the expression of a functional full-length trkC transcript for neurotrophin-3 (NT-3) receptor in oligodendroglia (OL) cells (Kumar and de Vellis, 1996). To date, the role of NT-3 and its signal transduction cascade in OL remains poorly defined. We report that the NT-3 re