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Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans

โœ Scribed by David V. Serreze; Yi-Guang Chen


Book ID
116577705
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
144 KB
Volume
26
Category
Article
ISSN
1471-4906

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The study of the immunopathogenesis of IDDM in patients is hampered by several restrictions: 1. The onset of IDDM is relatively late in the natural history of the immune process since almost 80-90% of islets have to be destroyed before insulin deficiency is diagnosed. 2. The site of the immune pro