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Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

✍ Scribed by John P. Driver; David V. Serreze; Yi-Guang Chen

Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
391 KB
Volume
33
Category
Article
ISSN
1863-2297

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The study of the immunopathogenesis of IDDM in patients is hampered by several restrictions: 1. The onset of IDDM is relatively late in the natural history of the immune process since almost 80-90% of islets have to be destroyed before insulin deficiency is diagnosed. 2. The site of the immune pro