Oestrogen treatment reduces duration of experimental allergic neuritis in rats and suppresses T cell responses to myelin
β Scribed by K. Strigard; R. Holmdahl; T. Olsson
- Book ID
- 114783158
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 595 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0001-6314
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Experimental autoimmune neuritis (EAN) is a CD4 Ψ T cell-mediated, inflammatory demyelinating disease of the peripheral nervous system (PNS) that serves as a model for Guillain-Barre Β΄syndrome (GBS) in humans. Various mouse and rat strains show different susceptibilities to EAN that can be induced b
Studies from our laboratory have shown that region 69-84 (synthetic peptide S49S) of myelin basic protein (MBP) defines an encephalitogenic sequence for experimental allergic encephalomyelitis (EAE) in Lewis rats. The most potent EAE inducers are the guinea pig MBP (Gp-MBP) and region 69-84, known a