Odontogenic tumours in the v-Ha-ras (TG · AC) transgenic mouse
✍ Scribed by J.T. Wright; L. Hansen; J. Mahler; C. Szczesniak; J.W. Spalding
- Book ID
- 113120500
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 967 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0003-9969
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Tg.AC transgenic mice have a transgene composed of a ζ-globin transcriptional control region, a v-Ha-ras coding region, and a simian virus 40 3´ polyadenylation signal sequence. Induced ectopic expression of the transgene by chemical treatment or full-skin-thickness wounding leads to the development
The Tg.AC transgenic mouse, which harbors an activated v-Ha-ras coding region that is fused to an embryonic zeta globin transcriptional control region and a 3' simian virus 40 polyadenylation sequence, rapidly develops epidermal papillomas in response to topical application of chemical carcinogens o
We have demonstrated that induction of transgene expression in the v-Ha-ras-transgenic TG.AC mouse is a critical event in skin tumorigenesis and that cutaneous papillomas arise from follicular epidermis after treatment with chemical carcinogens. The sensitivity of TG.AC mice to skin tumorigenesis, c