Tg.AC transgenic mice have a transgene composed of a ΞΆ-globin transcriptional control region, a v-Ha-ras coding region, and a simian virus 40 3Β΄ polyadenylation signal sequence. Induced ectopic expression of the transgene by chemical treatment or full-skin-thickness wounding leads to the development
Association of v-Ha-ras Transgene Expression with Development of Erythroleukemia in Tg.AC Transgenic Mice
β Scribed by Carol S. Trempus; Sandra Ward; Georgia Farris; David Malarkey; Randall S. Faircloth; Ronald E. Cannon; Joel F. Mahler
- Book ID
- 117022789
- Publisher
- American Society for Investigative Pathology
- Year
- 1998
- Tongue
- English
- Weight
- 684 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0002-9440
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The Tg.AC transgenic mouse, which harbors an activated v-Ha-ras coding region that is fused to an embryonic zeta globin transcriptional control region and a 3' simian virus 40 polyadenylation sequence, rapidly develops epidermal papillomas in response to topical application of chemical carcinogens o
We have demonstrated that induction of transgene expression in the v-Ha-ras-transgenic TG.AC mouse is a critical event in skin tumorigenesis and that cutaneous papillomas arise from follicular epidermis after treatment with chemical carcinogens. The sensitivity of TG.AC mice to skin tumorigenesis, c