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Ocular pharmacokinetics of a novel tetrahydroquinoline analog in rabbit: Compartmental analysis and PK–PD evaluation

✍ Scribed by Chandrasena R. Pamulapati; Ronald D. Schoenwald


Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
255 KB
Volume
101
Category
Article
ISSN
0022-3549

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Ocular pharmacokinetics of a novel tetra
✍ Chandrasena R. Pamulapati; Ronald D. Schoenwald 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB

The pharmacologically active compound (33% reduction in rabbit intraocular pressure recovery rate assay) 1-ethyl-6-fluoro-1,2,3,4-tetrahydroquinoline (MC4), which showed ocular hypotensive action and had optimum physicochemical properties, was characterized for its ocular absorption and distribution