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Ocular hypotensive action of a novel tetrahydroquinoline analog in rabbit: Physicochemical evaluation

✍ Scribed by Chandrasena R. Pamulapati; Ronald D. Schoenwald

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 189 KB
Volume: 100
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.22717

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The pharmacologically active compound (33% reduction in rabbit intraocular pressure recovery rate assay) 1-ethyl-6-fluoro-1,2,3,4-tetrahydroquinoline (MC4), which showed ocular hypotensive action and had optimum physicochemical properties, was characterized for its ocular absorption and distribution