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Octanol/Water Partition Coefficients of Sulfonamides: Experimental Determination and Calculation Using Physicochemical Descriptors

✍ Scribed by Raevsky, Oleg A.; Perlovich, German L.; Kazachenko, Vladimir P.; Strakhova, Nadezda N.; Schaper, Klaus-J.


Book ID
120165121
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
63 KB
Volume
54
Category
Article
ISSN
0021-9568

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Determination of octanol-water partition
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The use of liquid chromatography to estimate octanol-water partition coefficients, log k,,, has been demonstrated. The capacity factor with a mobile phase of 100% water, k,, has been found to be a useful chromatographic parameter. Values of k, were derived from a computer software package (Hipac-G),