Determination of octanol-water partition
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V. Makovskaya; J.R. Dean; W.R. Tomlinson; S.M. Hitchen; M. Comber
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Article
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1995
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Elsevier Science
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English
⚖ 835 KB
The use of liquid chromatography to estimate octanol-water partition coefficients, log k,,, has been demonstrated. The capacity factor with a mobile phase of 100% water, k,, has been found to be a useful chromatographic parameter. Values of k, were derived from a computer software package (Hipac-G),