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Determination of octanol-water partition coefficients using gradient liquid chromatography

✍ Scribed by V. Makovskaya; J.R. Dean; W.R. Tomlinson; S.M. Hitchen; M. Comber

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 835 KB
Volume: 315
Category: Article
ISSN: 0003-2670
DOI: 10.1016/0003-2670(95)00295-b

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✦ Synopsis

The use of liquid chromatography to estimate octanol-water partition coefficients, log k,,, has been demonstrated. The capacity factor with a mobile phase of 100% water, k,, has been found to be a useful chromatographic parameter. Values of k, were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k,, correlates well with both literature and isocratic LC-generated log k,, values. The gradient LC method could be extended to a wider range of test compounds.

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