3-Cyano-5-fluoro-N-arylbenzamides as neg
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Andrew S. Felts; Stacey R. Lindsley; Jeffrey P. Lamb; Alice L. Rodriguez; Usha N
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Article
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2010
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Elsevier Science
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English
β 224 KB
Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu 5 using a functional cell-based assay is described in this Letter. Further characterization of selected potent compounds in in vitro assays designed to measure their metabolic stability and protein