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Oct4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal

✍ Scribed by Christopher J. Lengner; Fernando D. Camargo; Konrad Hochedlinger; G. Grant Welstead; Samir Zaidi; Sumita Gokhale; Hans R. Scholer; Alexey Tomilin; Rudolf Jaenisch

Book ID
116890938
Publisher
Elsevier
Year
2007
Tongue
English
Weight
829 KB
Volume
1
Category
Article
ISSN
1934-5909

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## Abstract Cyclin‐dependent kinase 1 (Cdk1) is indispensible for the early development of the embryo. However, its role in maintaining the undifferentiated state of the embryonic stem (ES) cells remains unknown. In this study, we dissected the function of Cdk1 in mouse ES cells by RNA‐interference