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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

✍ Scribed by Park, In-kyung; Qian, Dalong; Kiel, Mark; Becker, Michael W.; Pihalja, Michael; Weissman, Irving L.; Morrison, Sean J.; Clarke, Michael F.

Book ID
109891034
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
336 KB
Volume
423
Category
Article
ISSN
0028-0836

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## Abstract Cyclin‐dependent kinase 1 (Cdk1) is indispensible for the early development of the embryo. However, its role in maintaining the undifferentiated state of the embryonic stem (ES) cells remains unknown. In this study, we dissected the function of Cdk1 in mouse ES cells by RNA‐interference