Ochratoxin A causes DNA damage in rats kidney
✍ Scribed by Ana-Marija Domijan; Davor Želježić; Vilim Žlender; Radovan Fuchs; Maja Peraica
- Book ID
- 119378968
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 96 KB
- Volume
- 164
- Category
- Article
- ISSN
- 0378-4274
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The nephrotoxic/carcinogenic mycotoxin ochratoxin A (OTA) occurs as a contaminant in food and feed and may be linked to human endemic Balkan nephropathy. The mechanism of OTA-derived carcinogenicity is still under debate, since reactive metabolites of OTA and DNA adducts have not been unambiguously
## Abstract Epidemiological studies indicate that ochratoxin A (OTA) may be involved in the pathogenesis of different forms of human nephropathies. Melatonin (MEL) displays antioxidant and free radical scavenger properties. In the present study, the effect of MEL on the oxidative stress induced by