Ochratoxin A Causes DNA Damage and Cytogenetic Effects but No DNA Adducts in Rats
β Scribed by Mally, Angela; Pepe, Gaetano; Ravoori, Srivani; Fiore, Mario; Gupta, Ramesh C.; Dekant, Wolfgang; Mosesso, Pasquale
- Book ID
- 126468593
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 393 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0893-228X
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π SIMILAR VOLUMES
The nephrotoxic/carcinogenic mycotoxin ochratoxin A (OTA) occurs as a contaminant in food and feed and may be linked to human endemic Balkan nephropathy. The mechanism of OTA-derived carcinogenicity is still under debate, since reactive metabolites of OTA and DNA adducts have not been unambiguously
Ochratoxin A (OTA), a nephrotoxic and carcinogenic mycotoxin, has been implicated as an etiologic agent in the Balkan endemic nephropathy (BEN), a chronic disease affecting populations in the Balkans. Compared with unaffected individuals, patients suffering from BEN and/or urinary tract tumors were