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Occurrence, specific binding sites and functional effects of endothelin in human cardiopulmonary tissue

✍ Scribed by Anette Hemsén; Anders Franco-Cereceda; Regis Matran; Anders Rudehill; Jan M. Lundberg

Book ID
115885936
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
911 KB
Volume
191
Category
Article
ISSN
0014-2999

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Effects and specific binding sites of endothelin in human lung preparations
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Endothelin binding in human isolated lung membrane fractions revealed a single class of high affinity recognition sites with a Kd of 1.33 +/- 0.15 nM and a Bmax of 9.61 +/- 1.44 pmol/mg protein. Endothelin inhibited [125I]endothelin binding with a Ki of 1.90 +/- 0.15 nM whereas structurally unrelate