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Occurrence of the same chromosome abnormalities in Ph+ and Ph− cells in chronic myeloid leukaemia. Evidence of a secondary origin of the Ph chromosome?

✍ Scribed by Emilio Donti; Alfonso Zaccaria; Alessandra Bassetti; Giovanna Venti; Barbara Giannini; Paolo Prontera; Erika Bianchi; Anna Valenti; Giuseppe Saglio; Anna Marina Liberati

Book ID: 108673946
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 440 KB
Volume: 135
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2006.06285.x

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In a small percentage of cases of chronic myelogenous leukemia (CML), where the Ph chromosome is masked because of highly complex translocations and sub-microscopic rearrangements, precise identification of chromosomal aberrations by routine banding techniques has been difficult. We report on a new