Occurrence of multiple JC virus variants with distinctive regulatory sequences in the brain of a single patient with progressive multifocal leukoencephalopathy
โ Scribed by Yoshiaki Yogo; Jing Guo; Takako Iida; Ken-Ichi Satoh; Fumiaki Taguchi; Hidehiro Takahashi; William W. Hall; Kazuo Nagashima
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 671 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0920-8569
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## Abstract Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system, which is thought to be a result of the reactivation of JC virus (JCV), a human polyomavirus. The disease occurs in individuals with immunosuppression and in recent years there has
Progressive multifocal leukoencephalopathy (PML), a viral-induced demyelinating disease, is becoming relatively common, while many diagnostic and pathogenetic aspects remain to be clarified. A study was therefore undertaken in 64 AIDS patients suffering from various neurological disorders, including