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Occurrence of a Putative SCF Ubiquitin Ligase Complex in Drosophila

✍ Scribed by Silvia N Bocca; Mariana Muzzopappa; Susana Silberstein; Pablo Wappner

Book ID
115588453
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
241 KB
Volume
286
Category
Article
ISSN
0006-291X

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✍ Kamura, T. πŸ“‚ Article πŸ“… 1999 πŸ› American Association for the Advancement of Scienc 🌐 English βš– 431 KB

The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex i