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Obstinate thrombosis during percutaneous coronary intervention in a case with heparin-induced thrombocytopenia with thrombosis syndrome successfully treated by argatroban anticoagulant therapy

✍ Scribed by Katsuyuki Sakai; Hirotaka Oda; Akihiro Honsako; Kazuyoshi Takahashi; Tutomu Miida; Norio Higuma

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 135 KB
Volume: 59
Category: Article
ISSN: 1522-1946
DOI: 10.1002/ccd.10536

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✦ Synopsis

Abstract

We describe a case of massive coronary thrombus after the coronary stenting due to heparin‐induced thrombocytopenia with thrombosis syndrome (HITTS). Only argatroban was able to resolve the thrombus. This is the first case in which argatroban successfully treated massive thrombus during percutaneous coronary intervention in a patient with HITTS. Cathet Cardiovasc Intervent 2003;59:351–354. © 2003 Wiley‐Liss, Inc.

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Heparin-induced thrombocytopenia and thrombosis syndrome (HITTS) is a severe complication of heparin caused by an antibody response to the heparin-platelet factor 4 complex which results in severe thrombosis. Heparin rechallenge in HllTS patients carries a high risk of inducing thrombosis. Antithrom