Observations on the active transport of bile salts by rat and hamster ileum in vitro
โ Scribed by Robert G. Faust; Shih-Min Liu Wu
- Book ID
- 113401157
- Publisher
- Elsevier Science
- Year
- 1966
- Weight
- 188 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0926-6585
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Everted sacs of rat and hamster jejunum were used to measure, simultaneously, fluid and glucose movement in the presence of various concentrations of bile salts. Low concentrations of sodium taurocholate or glycocholate did not affect the rates of fluid absorption or transport by either rat or hamst
## 4BSTRACT The results of this investigation indicate that with a progressive increase in the initial bile salt concentration within the mucosal and serosal compartments of everted sacs of rat and hamster ileum, a decrease i n tissue ATP levels is observed.
Bile salts are known to enhance the permeability of biological barriers but little is known about their effects on drug permeability across the blood-brain barrier (BBB). In this paper, the rat brain endothelial 4 (RBE4) cell monolayer incubated with astrocyte-conditioned medium was used as an in vi