✦ LIBER ✦

Observation of Varying Molecular Weight Distributions in Matrix-assisted Laser Desorption/Ionization Time-of-Flight Analysis of Polymethyl Methacrylate

✍ Scribed by Baochuan Guo; H. Chen; H. Rashidzadeh; X. Liu

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 175 KB
Volume: 11
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(19970422)11:7<781::aid-rcm915>3.0.co;2-t

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✦ Synopsis

The molecular weight distribution of a polymethyl methacrylate (PMMA 4K) standard was subjected to matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometric analysis. It was observed that the molecular weight distribution measured by MALDI-TOF could vary by as much as 27% even with a nearly same set of experimental parameters, and that this variation was due to mass discrimination against larger PMMA oligomers. Results indicate that the observed mass discrimination resulted mainly from the MALDI sample preparation and that a systematic study of the effects of sample preparation of MALDI-TOF analysis of polymers is needed to minimize potential mass discrimination. A brief explanation for the mass discrimination is also given.

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