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O6-methylguanine-DNA methyltransferase (MGMT) immunohistochemistry as a predictor of resistance to temozolomide in primary CNS lymphoma

✍ Scribed by Xiaoyin Jiang, David A. Reardon, Annick Desjardins…

Book ID
120753888
Publisher
Springer US
Year
2013
Tongue
English
Weight
180 KB
Volume
114
Category
Article
ISSN
0167-594X

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The O 6 -methylguanine-DNA-methyltransferase (MGMT) inactivator O 6benzylguanine (O 6 -beG) is currently under clinical investigation as a potential tumour-sensitising agent. In clinical trials its use has been associated with increased myelotoxicity and a reduced maximum tolerated dose (MTD) for BC