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O6-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C

โœ Scribed by Isabelle Passagne; Alexandre Evrard; Philippe Depeille; Pierre Cuq; Didier Cupissol; Laurence Vian


Book ID
113923752
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
351 KB
Volume
211
Category
Article
ISSN
0041-008X

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The P140K mutant of human O6-methylguani
โœ Lorna B. Woolford; Thomas D. Southgate; Geoffrey P. Margison; Michael D. Milsom; ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 155 KB

The O 6 -methylguanine-DNA-methyltransferase (MGMT) inactivator O 6benzylguanine (O 6 -beG) is currently under clinical investigation as a potential tumour-sensitising agent. In clinical trials its use has been associated with increased myelotoxicity and a reduced maximum tolerated dose (MTD) for BC