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O53. Multicenter validation of a lymph node metastasis gene expression signature for head and neck squamous cell carcinomas

โœ Scribed by F.K.J. Leusink; P.J. Slootweg; M.W.M. van den Brekel; R.J. Baatenburg de Jong; F.C.P. Holstege; R.P. Takes


Book ID
113833707
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
35 KB
Volume
47
Category
Article
ISSN
1368-8375

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Background. Prognosis of head and neck squamous cell carcinoma (HNSCC) is strongly associated with cervical lymph node metastasis. Cathepsin-D is a lysosomal protease expressed in all cells. Its role in extracellular matrix degradation is postulated to promote tumor invasion and metastasis. Increase