O.112 CpG island methylation of p16INK4A in odontogenic keratocyst
โ Scribed by S. Voyatzi; V. Jurisic; G. Koloutsos; A. Kyrgidis; N. Kechagias; M. Jurisic; F. Patakiouta; K. Vahtsevanos; K. Antoniades; P. Stravoravdi
- Book ID
- 119581459
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 51 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1010-5182
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## Silencing of p16 INK4a by methylation of the CpG islands in the promoter region has been found to be an alternative mechanism of inactivation in several tumors. However, in gastric carcinoma, the relationship between methylation status and the transcriptional silencing of the p16 gene remains t
## Abstract Loss of p16^INK4a^ protein expression has frequently been related to DNA methylation in association with gene silencing. Although the methylation status of exon1ฮฑ for p16^INK4a^ involvement in various cancers has been extensively analyzed, it has been pointed out that some inconsistenci