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O-silylated enolate phenylthialkylation: A synthesis of α,β-unsaturated 5- and 6-membered lactones.

✍ Scribed by Hassan A. Khan; Ian Paterson

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 134 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)85578-1

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✦ Synopsis

SwmnarY

ZnBr2-catalysed phenylthloalkylatlon of ketene bls(trlmethylsllyl)acetals, obtalned from carboxyllc acids, with appropriate a-chlorosulphldes can be used to prepare y-and 6lactones O-Sllylated enolate chemistry has recently produced new and improved methods for forming carbon-carbon bonds next to the carbonyl group l-3

In particular, alkylatlon of O-sllylated

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