N-Acyl protecting group in nucleoside derivatives can be selectively removed by treatment with zinc bromide in the presence of alcohols to give O-protected nucleosides. The di-p-anisylphenylmethyl (DMT) group has been extensively used for the protection of the 5'-hydroxyl function in polynucleoside
O-selective phosphorylation of nucleosides without N-protection
โ Scribed by Uchiyama, Mamoru; Aso, Yoshio; Noyori, Ryoji; Hayakawa, Yoshihiro
- Book ID
- 111657519
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 916 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
An O-selective phosphorylation of NH2-unprotected nucleosides has been achieved-via the aluminum alkoxides. Although a number of phosphorylation methods have been reported for the preparation of nuclectides, most of them have a common problem of chemoselec-
A number of reagents have been developed for the phosphorylation of nucleosides and other compounds of biological interest. Among them are several reagentsle7) which have been employed for the selective phosphorylation of the 5'-OH of unprotected nucleosides but they have the disadvantages of requir