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O-GlcNAc modification, insulin signaling and diabetic complications

✍ Scribed by T. Issad; E. Masson; P. Pagesy

Book ID
116404952
Publisher
Masson Editeur
Year
2010
Tongue
French
Weight
576 KB
Volume
36
Category
Article
ISSN
1262-3636

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## Abstract Here we report inhibition of phospholipase C‐β1 (PLC‐β1)‐mediated signaling by post‐translational glycosylation with β‐__N__‐acetylglucosamine (__O__‐GlcNAc modification). In C2C12 myoblasts, isoform‐specific knock‐down experiments using siRNA showed that activation of bradykinin (BK) r