The incidence of congenital heart disease was found to be 7.5% from 414 offspring born to women with phenylketonuria in the National Collaborative Study for Maternal Phenylketonuria (MPKU). Nutrient intake was studied in a subset of 22 offspring with congenital heart disease. The infants with congen
Nutrient intake and congenital heart defects in maternal phenylketonuria
โ Scribed by Kimberlee Michals-Matalon; Lawrence D. Platt; Phyllis Acosta Dr; Colleen Azen; Catherine A. Walla
- Book ID
- 114487878
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 48 KB
- Volume
- 187
- Category
- Article
- ISSN
- 1097-6868
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BACKGROUND: Congenital heart defects (CHDs) are among the most prevalent and serious of birth defects. Multiple maternal factors are thought to contribute to CHD development, including folate intake. Maternal DNA methylation, which is dependent on folate metabolism, may impact the risk of CHDs. Our
## Abstract ## BACKGROUND Few inquiries into periconceptional nutrition, other than folate, and risk of heart defects exist. We investigated the observed association between conotruncal heart defects and periconceptional vitamin use, as well as potential associations with other dietary nutrients.