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Nutrient effects on FK-506, a new immunosuppressant, production by Streptomyces sp. in a defined medium

✍ Scribed by Yeo Joon Yoon; Cha Yong Choi

Book ID
114294049
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
670 KB
Volume
83
Category
Article
ISSN
0922-338X

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We investigated the effect of an immunosuppressant FK-506 on histological change of islets, the onset of diabetes, and the change of spleen cell subsets in female non-obese diabetic mice. Mice administered intraperitoneally with FK-506 from 5 to 20weeks of age showed marked suppression of mononuclea