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Preventive effect of a new immunosuppressant FK-506 on insulitis and diabetes in non-obese diabetic mice

✍ Scribed by J. Miyagawa; K. Yamamoto; T. Hanafusa; N. Itoh; C. Nakagawa; A. Otsuka; H. Katsura; K. Yamagata; A. Miyazaki; N. Kono; S. Tarui

Publisher: Springer
Year: 1990
Tongue: English
Weight: 296 KB
Volume: 33
Category: Article
ISSN: 0012-186X
DOI: 10.1007/bf00405113

No coin nor oath required. For personal study only.

✦ Synopsis

We investigated the effect of an immunosuppressant FK-506 on histological change of islets, the onset of diabetes, and the change of spleen cell subsets in female non-obese diabetic mice. Mice administered intraperitoneally with FK-506 from 5 to 20weeks of age showed marked suppression of mononuclear cell infiltration (insulitis) at 10 weeks of age, Among the subsets of the spleen cells, a significant decrease in the population of Thyl.2-positive T cells (pan-T), L3T4-positive T cells (mainly helper/inducer), and Lyt2-positive T cells (mainly suppressor/cytotoxic) was observed in FK-506-treated mice. Furthermore, glucose tolerance of the mice at 15 weeks of age was clearly improved. Cumulative incidence observed up to 40 weeks of age was 86% in control mice and 23% in FK-506-treated mice (p <0.01). These data indicate that FK-506 has a preventive effect on insulitis and diabetes by the suppression of cell-mediated autoimmunity in non-obese diabetic mice.

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