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NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2

✍ Scribed by Idoya Lahortiga; Elena Belloni; Iria Vázquez; Xabier Agirre; María J. Larrayoz; Jose L. Vizmanos; Mikel Valgañón; Isabel Zudaire; Borja Sáez; María C. Mateos; Pier Paolo Di Fiore; María J. Calasanz; María D. Odero

Book ID
113512545
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
241 KB
Volume
157
Category
Article
ISSN
0165-4608

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The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part

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## Abstract __ETV6/TEL__ is the first transcription factor identified that is specifically required for hematopoiesis within the bone marrow. This gene has been found to have multiple fusion partners of which 16 have been cloned. Fluorescence in situ hybridization (FISH) analysis in a patient with