Molecular characterization of AML with i
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Frank G. RΓΌcker; Lars Bullinger; Alexander Gribov; Martin Sill; Richard F. Schle
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Article
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2010
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John Wiley and Sons
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English
β 540 KB
## Abstract In acute myeloid leukemia (AML), nonrandom clonal chromosome aberrations are detectable in βΌ55% of adult cases. Translocation t(8;21)(q22;q22) resulting in the 5β²__RUNX1__/3β²__RUNX1T1__ fusion gene occurs in βΌ8% of AML cases. Also, ins(8;21) and ins(21;8) have been described that show a