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Molecular cytogenetic investigations in a novel complex variant of t(8;21)(q22;q22) with ins(15;21)(q15;q22.2q22.3) in a patient with AML-M2 subtype

✍ Scribed by Prajakta Kokate; Firoz Ahmad; Rupa Dalvi; Bibhu Ranjan Das; Swarna Mandava


Book ID
113513349
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
710 KB
Volume
184
Category
Article
ISSN
0165-4608

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## Abstract In acute myeloid leukemia (AML), nonrandom clonal chromosome aberrations are detectable in ∼55% of adult cases. Translocation t(8;21)(q22;q22) resulting in the 5β€²__RUNX1__/3β€²__RUNX1T1__ fusion gene occurs in ∼8% of AML cases. Also, ins(8;21) and ins(21;8) have been described that show a