This paper simulates the sampling distributions of the rate parameter and the mean residence time (MRT) estimators for a specific two-compartment model. Two forms of measurement error, one additive and the other multiplicative, and two forms of weighting structures, one unweighted and the other wei
Numerical estimation of the noncompartmental pharmacokinetic parameters variance and coefficient of variation of residence times
โ Scribed by Robert D. Purves
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 440 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
The equation for the calculation of mean residence time of drug in plasma, t(p), is obtained. It is shown that the previously suggested calculation of t(p) considerably overestimates the true value in most cases. It is suggested that due to the possible initial (before establishing the uniform drug
The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi