Number of pregnancies and ovariectomy modify mammary carcinoma development in transgenic HER-2/neu female mice
β Scribed by Vladimir N. Anisimov; Irina G. Popovich; Irina N. Alimova; Mark A. Zabezhinski; Anna V. Semenchenko; Anatoli I. Yashin
- Book ID
- 117467680
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 153 KB
- Volume
- 193
- Category
- Article
- ISSN
- 0304-3835
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## Abstract The effect of various regimens of treatment with melatonin on the development of mammary tumors in HER2/neu transgenic mice was investigated. Female HERβ2/neu mice starting from the age of 2 months were kept under standard light/dark regimen and as given melatonin with tap water (20 mg/
Transgenic mice carrying the HER-2/neu proto-oncogene under tissue-specific transcriptional control of a mammary tumor virus long terminal repeat (Tg-MMTVneu mice) spontaneously develop mammary carcinomas. HER-2/neu is a tumor antigen that can be recognized by cytotoxic T lymphocytes if tumor cells
Female FVB/N HER-2/neu transgenic mice from the age of 2 months were subcutaneously injected with saline, the peptide Epitalon(R) (Ala-Glu-Asp-Gly) or with the peptide Vilon(R) (Lys-Glu) in a single dose of 1 microg/mouse for 5 consecutive days every month. Epitalon treatment reduced the cumulative