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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

✍ Scribed by Vladimir N. Anisimov; Lev M. Berstein; Peter A. Egormin; Tatiana S. Piskunova; Irina G. Popovich; Mark A. Zabezhinski; Irina G. Kovalenko; Tatiana E. Poroshina; Anna V. Semenchenko; Mauro Provinciali; Francesca Re; Claudio Franceschi

Book ID
113614684
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
224 KB
Volume
40
Category
Article
ISSN
0531-5565

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## Abstract The effect of various regimens of treatment with melatonin on the development of mammary tumors in HER2/neu transgenic mice was investigated. Female HER‐2/neu mice starting from the age of 2 months were kept under standard light/dark regimen and as given melatonin with tap water (20 mg/