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Nucleotides. Part XXV. Chemical synthesis of the hexaribonucleotide C-A-A-C-C-A

โœ Scribed by Misuzu Lchiba; Ramamurthy Charubala; Rajendra S. Varma; Wolfgang Pfleiderer

Publisher
John Wiley and Sons
Year
1986
Tongue
German
Weight
638 KB
Volume
69
Category
Article
ISSN
0018-019X

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โœฆ Synopsis

The chemical synthesis of the nbo-hexamer C-A-A-C-C-A has been achieved by two different routes applying the phosphotriester approach and using the @-nitropheny1)ethyl group for phosphate protection. The 2'-hydroxy groups as well as the terminal 2',3'-diol function have been blocked by the (lert-buty1)dimethylsilyl group as permanent protection throughout all the synthetic steps with great success. Final deblocking of all protective groups could be performed with 80% yield to give the hexamer 23. The various protected intermediates have been characterized by elemental analysis and UV spectra.

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