Nucleotides. II. 1 A New Procedure for the Conversion of Ribonucleosides to 2',3'-O-Isopropylidene Derivatives 2
โ Scribed by Hampton, Alexander
- Book ID
- 120812818
- Publisher
- American Chemical Society
- Year
- 1961
- Tongue
- English
- Weight
- 876 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
2'-Deoxy-2'-mercaptouridine (7) has been converted, via its 2'-5 3'-oalkylidine derivatives (g), into the corresponding 3'-G-alkyl-2'-deoxyuridfnea (2). 2',3'-Dideoxynucleosides [e.g. 2',3'-dideoxycytidine (1) and 2',3'-dideoxyinosine (z)] and 2',3'-dideoxynucleoside derivatives with 3'substituents
The combination of P 4 S 10 , sulfur, and hexamethyldisiloxane converts 3-oxoesters to 3H-1,2-dithiole-3thiones in yields generally superior to those obtained with Lawesson's reagent and without the need for chromatography to remove large amounts of phosphorous-containing byproducts.
An improved procedure for the stereospecific synthesis of olefhm from 1,2-dials via the corresponding thionocarbonate is described. The introduction of the versatile oleflnic function by &oxygenation of a 1,2-diol is a useful technique in organic synthesis. Although numerous procedures have appeare