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Nucleotide Variation Regulates the Level of Enhancement by Hypersensitive Site 2 of the β-Globin Locus Control Region

✍ Scribed by Solomon F. Ofori-Acquah; Michel R.A. Lalloz; D.Mark Layton

Book ID
115590172
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
95 KB
Volume
27
Category
Article
ISSN
1079-9796

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Study of the single nucleotide polymorphism (SNP) at the palindromic sequence of hypersensitive site (HS)4 of the human β-globin locus control region (LCR) in Indian population
✍ Ritushree Kukreti; Chandrika B-Rao; Swapan Kr Das; Madhusnata De; Geeta Talukder 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 54 KB 👁 2 views

## Abstract LCR, a genetic regulatory element, was examined in β‐thalassemia patients who do not show any mutation in the β‐globin genes. We sequenced LCR‐HS2, HS3, and HS4 in samples from 16 such patients from the Indian population and found only one SNP A‐G in the inverted repeat in HS4. A signif