Nucleosides LXXXI. An approach to the synthesis of C-C linked β-D-ribofuranosyl nucleosides from 2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl chloride
✍ Scribed by Hiroshi Ohrui; Jack J. Fox
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- French
- Weight
- 203 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
In recent years a new class of naturally-occurring nucleosides containing the unusual C-ribosyl linkage ("C-nucleosides") has been discovered 2,3 . Several synthetic routes directed to C-nucleosides have been reported 3-a . Recently, Hanessian and Pernet 9 reported the successful
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We would like to report the synthesis of a derivative of the new heterocyclic ring system pyrrolo[4,3,2-de]pyrimido[4,5-clpyridazine. The reaction of 4-chloro-5-cyano-7-(g-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidine (I) (3) with methylhydrasine should have furnished 5-cyano-4-(N-l-methylhydrazino)-7-(B
The reaction of 2,3:5,6-di-0-isopropylidene-cu-D-mannofuranose with (3methoxycarbonyl-2-oxopropylidene)triphenylphosphorane, catalysed by benzoic acid in dry benzene, gives methyl 4-(2,3:5,6-di-O-isopropylidene-cr-and -@-mannofuranosyl)-3-oxobutanoate in good yield. These compounds are easily transf