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Nucleosides-126: Selective methylation of the C-nucleoside, ψ-isocytidine and its 2$́-deoxy analog. Synthesis of 1-methyl, 3-methyl and 4-o-methyl derivatives

✍ Scribed by K.W. Pankiewicz; A. Matsuda; K.A. Watanabe; J.J. Fox


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
619 KB
Volume
40
Category
Article
ISSN
0040-4020

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Recently we reported [1,2] the synthesis and antibacterial activity of 3-deoxy-5-O-(4deoxymycaminosyl)tylonolide ( 1). This study demonstrated that removal of both the 3and 4'-hydroxy groups of 5-O-mycaminosyltylonolide greatly enhances the activity. To prepare a more-active derivative than 1, intro