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Nucleoside H-Phosphonates. 15. Preparation of Nucleoside H-Phosphonothioate Monoesters from the Corresponding Nucleoside H-Phosphonates

✍ Scribed by Zain, Rula; Stroemberg, Roger; Stawinski, Jacek


Book ID
118742906
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
583 KB
Volume
60
Category
Article
ISSN
0022-3263

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Aryl Hphosphonates. 8. Simple and effic
✍ Inger Kers; Annika Kers; Jacek Stawiński; Adam Kraszewski 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 257 KB

An efficient method for the preparation of nucleoside 3'-H-phosphonothioate monoesters was developed. It consists of phosphonylation of suitably protected nucleosides with diphenyl H-phosphonate to produce nucleoside phenyl H-phosphonates, followed by their sulfhydrolysis with hydrogen sulfide.